CHOLECYSTECTOMY PROMOTES THE DEVELOPMENT OF COLORECTAL CANCER BY THE ALTERNATION OF BILE ACID METABOLISM AND THE GUT MICROBIOTA

Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota

The incidence and mortality of colorectal cancer (CRC) have been markedly increasing worldwide, causing a tremendous burden to the healthcare system.Therefore, it is crucial to investigate the risk factors and pathogenesis of CRC.Cholecystectomy is a gold standard procedure for treating symptomatic cholelithiasis and gallstone diseases.The rhythm o

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Molecular Mechanism of the Cell Death Induced by the Histone Deacetylase Pan Inhibitor LBH589 (Panobinostat) in Wilms Tumor Cells.

Wilms tumor (WT) is an embryonic kidney cancer, for which histone acetylation might be a therapeutic target.LBH589, a novel targeted agent, suppresses histone deacetylases in many tumors.This study investigated the antitumor activity of LBH589 in SK-NEP-1 and G401 cells.SK-NEP-1 and G401 cell growth was assessed by CCK-8 and in nude mice experiment

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